SrasV1, Main, Exploration, bibRecord, 005F86

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.

Identifieur interne : 005F86 ( Main/Exploration ); précédent : 005F85; suivant : 005F87

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.

Auteurs : J. Cinatl [Allemagne] ; B. Morgenstern ; G. Bauer ; P. Chandra ; H. Rabenau ; H W Doerr

Source :

Lancet (London, England) [ 1474-547X ] ; 2003.

RBID : pubmed:12814717

Descripteurs français

KwdFr :
- Acide glycyrrhizique (pharmacologie), Animaux, Antiviraux (pharmacologie), Cellules Vero, Coronavirus (), Coronavirus (physiologie), Glycyrrhiza (), Humains, Réplication virale (), Syndrome respiratoire aigu sévère (traitement médicamenteux).
MESH :
- pharmacologie : Acide glycyrrhizique, Antiviraux.
- physiologie : Coronavirus.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Coronavirus, Glycyrrhiza, Humains, Réplication virale.

English descriptors

KwdEn :
- Animals, Antiviral Agents (pharmacology), Chlorocebus aethiops, Coronavirus (drug effects), Coronavirus (physiology), Glycyrrhiza (chemistry), Glycyrrhizic Acid (pharmacology), Humans, Severe Acute Respiratory Syndrome (drug therapy), Vero Cells, Virus Replication (drug effects).
MESH :
- chemical , pharmacology : Antiviral Agents, Glycyrrhizic Acid.
- chemistry : Glycyrrhiza.
- drug effects : Coronavirus, Virus Replication.
- drug therapy : Severe Acute Respiratory Syndrome.
- physiology : Coronavirus.
- Animals, Chlorocebus aethiops, Humans, Vero Cells.

Abstract

The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.

DOI: 10.1016/s0140-6736(03)13615-x
PubMed: 12814717

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.</title>
<author><name sortKey="Cinatl, J" sort="Cinatl, J" uniqKey="Cinatl J" first="J" last="Cinatl">J. Cinatl</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Virology, Frankfurt University Medical School, Paul-Ehrlich Str 40, D-60596, Frankfurt, Germany. cinatl@em.uni-frankfurt.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Virology, Frankfurt University Medical School, Paul-Ehrlich Str 40, D-60596, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morgenstern, B" sort="Morgenstern, B" uniqKey="Morgenstern B" first="B" last="Morgenstern">B. Morgenstern</name>
</author>
<author><name sortKey="Bauer, G" sort="Bauer, G" uniqKey="Bauer G" first="G" last="Bauer">G. Bauer</name>
</author>
<author><name sortKey="Chandra, P" sort="Chandra, P" uniqKey="Chandra P" first="P" last="Chandra">P. Chandra</name>
</author>
<author><name sortKey="Rabenau, H" sort="Rabenau, H" uniqKey="Rabenau H" first="H" last="Rabenau">H. Rabenau</name>
</author>
<author><name sortKey="Doerr, H W" sort="Doerr, H W" uniqKey="Doerr H" first="H W" last="Doerr">H W Doerr</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:12814717</idno>
<idno type="pmid">12814717</idno>
<idno type="doi">10.1016/s0140-6736(03)13615-x</idno>
<idno type="wicri:Area/PubMed/Corpus">003315</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003315</idno>
<idno type="wicri:Area/PubMed/Curation">003315</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003315</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003231</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003231</idno>
<idno type="wicri:Area/Ncbi/Merge">000184</idno>
<idno type="wicri:Area/Ncbi/Curation">000184</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000184</idno>
<idno type="wicri:Area/Main/Merge">006480</idno>
<idno type="wicri:Area/Main/Curation">005F86</idno>
<idno type="wicri:Area/Main/Exploration">005F86</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.</title>
<author><name sortKey="Cinatl, J" sort="Cinatl, J" uniqKey="Cinatl J" first="J" last="Cinatl">J. Cinatl</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Virology, Frankfurt University Medical School, Paul-Ehrlich Str 40, D-60596, Frankfurt, Germany. cinatl@em.uni-frankfurt.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Virology, Frankfurt University Medical School, Paul-Ehrlich Str 40, D-60596, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morgenstern, B" sort="Morgenstern, B" uniqKey="Morgenstern B" first="B" last="Morgenstern">B. Morgenstern</name>
</author>
<author><name sortKey="Bauer, G" sort="Bauer, G" uniqKey="Bauer G" first="G" last="Bauer">G. Bauer</name>
</author>
<author><name sortKey="Chandra, P" sort="Chandra, P" uniqKey="Chandra P" first="P" last="Chandra">P. Chandra</name>
</author>
<author><name sortKey="Rabenau, H" sort="Rabenau, H" uniqKey="Rabenau H" first="H" last="Rabenau">H. Rabenau</name>
</author>
<author><name sortKey="Doerr, H W" sort="Doerr, H W" uniqKey="Doerr H" first="H W" last="Doerr">H W Doerr</name>
</author>
</analytic>
<series><title level="j">Lancet (London, England)</title>
<idno type="eISSN">1474-547X</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus (drug effects)</term>
<term>Coronavirus (physiology)</term>
<term>Glycyrrhiza (chemistry)</term>
<term>Glycyrrhizic Acid (pharmacology)</term>
<term>Humans</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Vero Cells</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide glycyrrhizique (pharmacologie)</term>
<term>Animaux</term>
<term>Antiviraux (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Coronavirus ()</term>
<term>Coronavirus (physiologie)</term>
<term>Glycyrrhiza ()</term>
<term>Humains</term>
<term>Réplication virale ()</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhizic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Glycyrrhiza</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide glycyrrhizique</term>
<term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Coronavirus</term>
<term>Glycyrrhiza</term>
<term>Humains</term>
<term>Réplication virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>District de Darmstadt</li>
<li>Hesse (Land)</li>
</region>
<settlement><li>Francfort-sur-le-Main</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bauer, G" sort="Bauer, G" uniqKey="Bauer G" first="G" last="Bauer">G. Bauer</name>
<name sortKey="Chandra, P" sort="Chandra, P" uniqKey="Chandra P" first="P" last="Chandra">P. Chandra</name>
<name sortKey="Doerr, H W" sort="Doerr, H W" uniqKey="Doerr H" first="H W" last="Doerr">H W Doerr</name>
<name sortKey="Morgenstern, B" sort="Morgenstern, B" uniqKey="Morgenstern B" first="B" last="Morgenstern">B. Morgenstern</name>
<name sortKey="Rabenau, H" sort="Rabenau, H" uniqKey="Rabenau H" first="H" last="Rabenau">H. Rabenau</name>
</noCountry>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Cinatl, J" sort="Cinatl, J" uniqKey="Cinatl J" first="J" last="Cinatl">J. Cinatl</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F86 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005F86 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:12814717
   |texte=   Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:12814717" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.